In the summer of 1972 in Madison, Pennsylvania, Vada Sultenfuss (Anna Chlumsky) is an 11-year-old tomboy and a hypochondriac. Vada's father, Harry Sultenfuss (Dan Aykroyd), is an awkward widower who does not understand his daughter, so he constantly ignores her. His profession as a funeral director, for which the Sultenfuss' residence serves as a funeral parlor, has led Vada to develop an obsession with death. She thinks that she killed her mother, who died giving birth to her. Vada regularly tends to her invalid grandmother Gramoo (Ann Nelson), who suffers from Alzheimer's disease. Harry's brother Phil (Richard Masur), who lives nearby, also stops by frequently to help out the family.Vada is teased by other girls and her best friend is Thomas J. Sennett (Macaulay Culkin), an unpopular boy who is allergic to "everything." One day, Vada gets squirted with a water gun by Thomas J., which makes Vada chase Thomas J. into the woods. Once there, they throw rocks at a hornet's nest and end up getting chased by hornets. During the encounter, Vada loses her mood ring. Vada's summer begins well. She befriends Shelly DeVoto (Jamie Lee Curtis), the new make-up artist at her father's funeral parlor, who provides her with some much needed guidance. She is also infatuated with her teacher, Mr. Bixler (Griffin Dunne), and steals some money from Shelly's trailer to attend a summer writing class that he is teaching. Soon things start to fall apart.Her father and Shelly start dating and get engaged. Vada experiences her first menstrual cycle; Shelly explains it after Vada runs around the house yelling that she is hemorrhaging. A couple of days later, Vada and Thomas J. sit at the dock by the river, where they share an innocent first kiss. Thomas J. later goes into the forest to look for Vada's mood ring and finds it, but is stung by hornets from the detached nest, which Harry believed he had stepped on, and dies of an allergic reaction. Soon after, Vada discovers that Mr. Bixler is about to get married to someone else. Shelly and Harry get into an argument at Thomas J.'s funeral, and Shelly angrily tells Harry that life isn't just about death, as well as not to ignore the living, especially his daughter.Vada's grief manages to mend the rift between her and her father. She learns that her mother's death after her birth wasn't her fault (since her father explains to her that things like mothers dying in childbirth are not anybody's fault; they just happen without explanation). Eventually Vada makes a new friend, and not only comes to terms with her pain and grief, but also overcomes some of her previous issues as well.
- Aline, Alisa, Buzz, Cara, Caroline, Cluadio, David, Emily, Eric, Estuardo, Frances, Francesco, Garret, Jared, Jessie, Kaliegh, Keiko, Kenny, Kortney, Kyle, Lynese, Matt, Maya, Mike, Nick, Noreen, Pablo, Rachel, Ray, Shing Ying, Taylor, Zoe, Nat, Alex, Thomas Batuello, Allie DiMeco, David Levi, Qaasim Middleton, Cooper Pillot, Jesse Draper, Michael Wolff, Pepper, Molly, July, Duffy, Kate, Tessie, Oliver, DJ, Stephanie, Michelle, Aaron, Denise, Derek, Harry, Rusty, Teddy, Walter, The All That Gang, The Shake It Up Gang, Zack, Cody, Maxx, Sarah Baker, Jake Baker, Henry Baker, Lorraine Baker, Nigel Baker, Kyle Baker, Kim Baker, Jessica Baker, Mike Baker, Mark Baker, Leo Little, Cake, Amy, Miracle, Benjamin, Max Keeble, Megan, Robe, Richelle, Ben Hilton, Jamie, Max, Becca, Nicky, Jeannie, The Flash/Tony, Crispin, Dylan, Duncan, Sean, Tony's Brother, German Speaking Boy, Juel, Erin, Benny, Lina, Henry, Kiki, Aldo and his friends, Alvin, Brittany, Simon, Jeanette, Theodore, Eleanor, Tommy, Dil, Chuckie, Phil, Lil, Kimi, Angelica, Susie, Emily Yeung, Daniel Cook, Ramona, Tina, Casper, Wendy, Carly, Spencer, Sam, Gibby, Freddie, Ed, Edd, Eddy, The Baby-Sitters Club Gang, Kids World's Adventures Team, Bob the Tomato, Larry the Cucumber, Junior Asparagus, Laura Carrot, Jimmy and Jerry Gourd, Mr. Nezzer, Mr. Lunt, Jean-Claude and Phillipe, Alice, Hercules, Meg, Phil, Pegasus, Pocahontas, Meeko, Flit, Princess Aurora, Peter Pan, Tinker Bell, Terence, Iridessa, Rosetta, Fawn, Silvermist, Lucky, Cadpig, Rolly, Spot, Woody, Buzz Lightyear, Jessie, Rex, Hamm, Slinky Dog, Mr. Potato Head, Mrs. Potato Head, the Squeeze Toy Aliens, Bullseye, Dolly, Mr. Pricklepants, Buttercup, Trixie, Chuckles the Clown, The Teenage Mutant Ninja Turtles, The Smurfs (Papa Smurf, Smurfette, Gutsy Smurf, Brainy Smurf, Clumsy Smurf, and Grouchy Smurf), Oscar the Sharkslayer, Lenny the Shark, Angie, Don Lino, Mr. Sykes, Ernie and Bernie, Luca, Boog and Elliot, Wolf and Twitchy, Rodney Copperbottom, Cappy, Bigweld, Wonderbot, Fender Pinwheeler, Piper Pinwheeler, Lug, Diesel Springer, Crank Casey, Aunt Fanny, Dexter, DeeDee, I.M. Weasel, I.R. Babboon, Cow and Chicken, Mac Foster, Bloo, Coco, Wlit, Eduardo, Frankie Foster, Mr. Herriman, Ash Ketchum, Pikachu, Misty, Togepi, Brock, May, Max (Pokemon), The Powerpuff Girls (Blossom, Bubbles, and Buttercup), Blue the Puppy, Ploka Dots, Slippery Soap, Tickety Tock, Mr. Salt, Mrs. Pepper, Paprika, Periwinkle, Roar E. Saurus, Fredrica the Birthday Girl, Zazu, Rafiki, Kovu, Kiara, the All-Grown Up Gang and their families, Carly Shay, Sam Puckett, Freddie Benson, Spencer Shay, Gibby, Tori Vega, Trina Vega, Cat Valentine, Beck Oliver, Jade West, Robbie Shapiro, Rex (puppet), Popeye, Olive Oyl, Popeye's Nephews (Peepeye, Poopeye, Pipeye, and Pupeye), Wimpy, The Penguins of Madagascar (Skipper, Kolwalski, Rico, and Private), King Julien, Maurice, Mort, Marlene, Mickey Mouse, Minnie Mouse, Goofy, Donald Duck, Daisy Duck, Pluto, Max Goof, Horace Horsecollar, Clarabelle Cow, Ludwig von Drake, Scrooge McDuck, Huey, Dewey, Louie, Webby, Launchpad McQuack, Chip and Dale, Gadget Hackwrench, Monterey Jack, Zipper, Lilo, Stitch, Pleakey, Jumba, Nani, the Muppets (Kermit the Frog, Miss Piggy, Fozzie Bear, Gonzo, Bean Bunny, Rowlf the Dog, Scooter, Rizzo the Rat, Waldorf and Statler, Pepe the King Prawn, Sweetums, Thog, Sam the Eagle, the Electric Mayhem and Walter), The Simpsons (Homer, Marge, Bart, Lisa, and Maggie), Milhouse Van Houten, Ned Flanders, Edna Krabappel, Principal Skinner, Krusty the Clown, Bugs Bunny, Daffy Duck, Porky Pig, Sylvester, Tweety, Foghorn Leghorn, The Tiny Toons, Yakko Warner, Wakko Warner, Dot Warner, Mario, Luigi, Princess Toadstool, Toad, Yoshi, Donkey Kong, Diddy Kong, Sonic the Hedgehog, Miles "Tails" Prower, Knuckles the Echidna, Amy Rose, Cream the Rabbit, Cheese the Chao, Shadow the Hedgehog, Rouge the Bat, E-123 Omega, Big the Cat, Team Chaotix (Vector the Crocodile, Espio the Chameleon, and Charmy the Bee), Silver the Hedgehog, Blaze the Cat, Pac-Man, Cylindria, Spiral, Sir Cumference, Skeebo, Braces, Spyro the Dragon, Sparx the Dragonfly, Banjo and Kazooie The Griffins (Peter, Lois, Chris, Meg, Brian, and Stewie), Glenn Quagmire, Cleveland Brown, Sid, Diego, Manny, Ellie, Peaches, Crash and Eddie, Blu, Jewel, Rafael, Luiz, Harry Potter, Hermoine Granger, Ron Weasley, Hagrid, Professor Snape, Madame Bluberry, Petunia Rhubarb, Chanticleer, Hubie, Rocko, Courage the Cowardly Dog, Johnny Bravo, The Vultures, Pinocchio, Jiminy Cricket, Geppetto, Sulley and Mike, Celia Mae, Roz, the Incredibles (Bob, Helen, Dash, Violet, Jack-Jack, and Frozone), Kenai, Koda, Cinderella, Snow White, Ariel, Flounder, Belle, Lumiere, Cogsworth, Mrs. Potts, Chip the Cup, Princess Jasmine, Mulan, Princess Tiana, Princess Merida, Phineas and Ferb, Candace Flynn, Isabella Garcia-Shapiro, Stacy Hirano, Buford, Baljeet, And Perry the Platypus, will guest star in this film.